Fox-Fordyce disease: two cases in patients with Turner syndrome.

Sir, Fox-Fordyce disease (FFD) occurs as a chronic, itchy, papular skin eruption principally located in the apocrine gland-bearing areas (1, 2). Although it usually appears in a symmetrical distribution on the axillae and pubic area, it can also occasionally a¡ect the labia, perineum, mammary areolae, presternal area, umbilicus and the medial aspect of the upper thighs. Hair growth in the a¡ected regions is sparse or absent. Apocrine sweat is not produced at the ori¢ces of follicles of the a¡ected glands. Sometimes intense itching is present, apparently activated by intense sweating or by emotional excitation. More than 90% of reported cases have been observed in women between 13 and 35 years of age. The histologic picture is characterized by obstruction of the apocrine duct at its entrance into the follicular wall. The aims of this paper are to report two cases of FFD in two patients with Turner syndrome under treatment with growth hormone (GH) and to speculate as to whether these two conditions are correlated in any way.